2021 Topic: Tumor suppressor genes Schedule: 11/16 by Bi He Cai Selected paper: A selective activator and anticancer agent to improve colorectal cancer therapy Cell Rep. 2021 Apr 13;35(2):108982.
12/2 by Ruo Yu Liao & Zhi Yu Bai Selected paper: Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E906-E915
12/7 by Rui Yu Lu & Si Jie Yu Selected paper: GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner J Exp Clin Cancer Res. 2019 Apr 8;38(1):152.
12/14 by Fang Yu Yeh & Yu Jung Yang Selected paper: Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs Stem Cell Rep. 2021 Nov 16;S2213-6711(21)00554-3.
12/20 by Ming Han Wu & Yu Rou Lin Selected paper: Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors EMBO Rep. 2021 may 5;22(5):e51412.
12/28 by Wei Hsin Kuo & Wei Chen Wu Selected paper: Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells Nat Commun. 2021 Sep 15;12(1):5463.
2022 Topic: Stemness genes Schedule:
2022/05/12 by Bi He Cai Selected paper: DOT1L is a novel cancer stem cell target for triple negative breast cancer. Clin Cancer Res . 2022 May 2;28(9):1948-1965
2022/05/19 by Rui Yu Lu & Si Jie Yu Selected paper: Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer. Cell Oncol (Dordr) . 2020 Jun;43(3):431-444.
2022/05/26 by Wei Hsin Kuo & Wei Chen Wu Selected paper: Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling J Transl Med. 2021 Jul 19;19(1):311.
2022/05/26 by Ming Han Wu & Fang Yu Yeh Selected paper: SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium Stem Cells. 2019 Mar;37(3):417-429. 2022/06/02 by Yu Rou Lin & Chu Hsien Shih Cancer stemness, intratumoral heterogeneity, and immune response across cancers. Proc Natl Acad Sci U S A . 2019 Apr 30;116(18):9020-9029.
2022/06/09 by Zhi Yu Bai & Yun-Chien Hsu The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression. Sci Adv . 2019 Jul 17;5(7):eaaw6710.
2022/06/09 by Yi Zhen Tsai & Ying Chen Lin A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation. J Exp Clin Cancer Res . 2021 Jun 30;40(1):218.
2022 new Tumor suppressor genes journal club Schedule:
2022/11/28 by Bi He Cai Selected paper: Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown. Cancer Discov . 2021 Nov;11(11):2828-2845.
2022/12/05 by Alexa Janeth Escobar Pastor and Danny Danilo Zul Selected paper: LKB1 phosphorylation and deactivation in lung cancer by NNAL, a metabolite of tobacco-specific carcinogen, in an isomer-dependent manner. Oncogene . 2022 Aug;41(33):4042-4054.
2022/12/12 by Ming Han Wu & Yun-Chien Hsu Selected paper: Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors. Nat Commun. 2022 Jun 28;13(1):3706.
2022/12/12 by Yu Rou Lin & Fang Yu Yeh Selected paper: Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2119644119.
2022/12/12 by Ko Fang Liu & Tze You Wu & Kuan Yo Wu Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nat Commun. 2020 Oct 14;11(1):5156.
2022/12/19 by Rui Yu Lu & Si Jie Yu Selected paper: MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2102420118.